Treatment with Nilotinib

Nilotinib is taken orally. Unlike some chemotherapy agents, it is not given by IV drip. It is "bioavailable" if swallowed. The manufacturer makes capsults with 200 mg of the active drug; the rest is filler.

Like any medicine, especially any chemotherapy agent, it is important to discuss nilotinib with your doctor before taking. Your doctor probably will not let you take it if you are pregnant or might become pregnant. Nilotinib potentially interferes with a wide range of antibiotics. You need to be careful of other chemotherapy drugs, too. This is why chemotherapy should only be administered under supervision of highly trained medical oncologists.

Researchers found Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs.

A write-up of targeted therapy for leukamia speculated the future CML treatments could employ combination regimens two or more agents.

The aminopyrimidine inhibitor AMN107 (Nilotinib) was rationally designed to antagonize the aberrant tyrosine kinase activity of Bcr-Abl-positive cells.